Newspaper and blogs reporting Dr S V Prabhu’s talk on mirror neurons in Srilanka
Site Mentioning Dr S V Prabhu as the initial contributer to the creation of a EEG laboratory for research in meditation
Recent conference in Bali Indonesia ,where a paper was read
My current institute
DBS (deep brain stimulation )
DBS is a modality of treatment of neurological diseases for which there are not many satisfactory drugs available at least today.DBS for Parkinson's Disease was first performed here in Grenoble by Hon .Prof.Dr Alim Benabid. .He pioneered the DBS in the world.
DBS involves stimulation of specific areas of brain with High frequency current.The system contains depth electrodes ,a programmable stimulator and its battery
The putative mechanism with which DBS helps in clinical relief can be enumerated below
DBS as a ‘information processing’ modulator
To borrow the terminology from the computer sciences ,the pathology can be summarized as network dysfunction
a)in ‘normal’ state there is very little synchronicity and pathological rhythms if generated are not synchronized over distant region
b)in diseased state the pathological rhythms are synchronized over a distance .the information and sequential processing of input is altered due to miscued signals from these pathological rhythms.
c)High frequency DBS acts as a ‘barrier è white noise’ and the information carried by pathological rhythms is not used for subsequent processing
Other mechanisms with which DBS produces clinical benefit might be occurring at cellular and microscopic levels. These effects are postulated as basis for long term benefits seen in DBS and effects seen even after the DBS is turned off;
DBS might affect gene expression
the turning on and of gene could be affected
The gene responsible for programmed cell death signal(often changed in neurodegenerative disorders) and apoptosis might be getting switched off ;
Production of neuroprotective molecules could be getting altered ;
At synaptic level the DBS might be involved in
augmentation of inhibitory or excitatory conduction
long term potentiation of synapse
Antidromic stimulation of the cell body
Changes in neurotransmitter synthesis and release .
The horizons are broadening ''''....
From the initial use in Tremor Predominant Parkinson's Disease the application of DBS has expanded and now covers other movement disorders ,neuropsychiatric diseases showing suboptimal response /resistant to current drugs ,Epilepsy ,Obesity and neuroprotection .