Subodh Prabhu & Neurosciences

Neurosciences ,Functional Neurosurgery ,Deep Brain Stimulation ,Indian Philosophy

My current work

Deep Brain Stimulation for control of Epilepsy -research


Équipe Nanomedecine et cerveau (eq 7)
GIN centre de recherche INSERM U 836
Grenoble Institut des Neurosciences
Bâtiment Edmond J. Safra - Chemin Fortuné Ferrini
Université Joseph Fourier
Sité Santé à La Tronche
BP 170
380042 GRENOBLE Cedex 9

http://neurosciences.ujf-grenoble.fr/index_eng.php

 

  seminar/presentation 

Dernier  séminaire (Hebdo)

12/12/09

 ISHN ,Paris 15/06/10  


 Hebdo :13/O7/10

  

Brains in Dialogue (BID) 3 rd Workshop 'Deep Brain stimulation '

 

Warsaw (Poland )  20  September 2010

Hebdo    22/03/11

  Socieété Des neurosciences Marseille  24-27 May 2011

   "Re-thinking the Monstrous"    Munich  Germany 1-3 June 2011

   8 th World congress ,IBRO     Florence  Italy   14-18 July 2011  

 

Prochain

 

 IES  congress Roma 27 Aug     2011 

 

 

 

Recent Abstracts

 

 http://www.abstractstosubmit.com/ibro2011/abstracts/

 

Title:Could basal ganglia input structures control ongoing focal motor seizures? Results of Subthalamic nucleus DBS and further plan in a primate model
B440
Session:POSTER PRESENTATION - Saturday, July 16
Presenter:Shivadatta Prabhu
Institute:Grenoble Institute of Neurosciences-INSERM U836, UJF-CEA-CHU, Grenoble, France   France

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B440 Could basal ganglia input structures control ongoing focal motor seizures? Results of Subthalamic nucleus DBS and further plan in a primate model
S.V. PRABHU1, B. PIALLAT1,2, S. MICHALLAT1, A. SHERDIL1, O. DAVID1,2 & S. CHABARDÈS1,2,3
1Grenoble Institute of Neurosciences-INSERM U836, UJF-CEA-CHU, Équipe 11, Fonctions Cérébrales et Neuromodulation, Grenoble, France, 2Université Joseph Fourier, Grenoble, France, 3CHU, Department of Neurosurgery Aarhus University Hospital, Grenoble, France
Epileptic seizures arise from pathological synchronization of neuronal ensemble and those originating from primary motor cortex are often pharmacoresistent, and many times unsuitable for resective surgery because of location of epileptic focus in eloquent area. Basal ganglia play important role in seizure propagation. Microelectrode recordings performed during previous studies indicated that input structures of basal ganglia such as GPe, Putamen and Subthalamic nucleus (STN) are strongly modified during seizures. For example the mean firing rate of neurons of the STN and Putamen increased and the percentage of oscillatory neurons synchronized with the ictal EEG was higher during seizures as compared to interictal periods. Pilot studies in humans have shown the possible beneficial effect of chronic DBS applied to STN in treatment of pharmacoresistant motor seizures.
A primate model of focal motor epilepsy using intracortical injection of penicillin was generated .Streotactic implantation of DBS electrodes in STN ,Putamen was performed .Continuous 130 Hz stimulation was carried with stimulator embedded in back.
Results: Data presented here is related to STN stimulation .A total of 1270 seizures were induced during 31 sessions in 2 primates. The occurrence of first seizure was significantly delayed as compared to sham situation. Total time spent in focal seizures was significantly reduced by ≥60% on an average (p ≤0.05) after STN stimulation, due to a significant decrease in the number of seizures especially so during the first 3 hours after stimulation. The duration of individual seizures reduced moderately. There was a trend of a decrease in interictal spikes during ON stimulation. Bipolar and monopolar stimulation modes were equally effective.This study provides initial original data in primates showing the potential therapeutic effect of chronic HFS-STN DBS to treat focal motor seizures .Further plan to simultaneously stimulate the STN and Putamen and rationale for stimulating both structures is presented .
Session Details
Session Title: 16. Neurological disorders (Epilepsy)
Session Date: Saturday, July 16

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 http://www.abstractstosubmit.com/ibro2011/abstracts/

Title:The prefix ‘Neuro’ in terms like neuromarketing ,neuroeconomics: truly transdisciplinary approaches or just catchy hyped up syllables?
H013
Session:POSTER PRESENTATION - 20. History, teaching, neuroethics, awareness & social impact
Presenter:Shivadatta Prabhu
Institute:Grenoble Institute of Neurosciences-INSERM U836, UJF-CEA-CHU, Grenoble, France   France

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H013 The prefix 'Neuro' in terms like neuromarketing ,neuroeconomics: truly transdisciplinary approaches or just catchy hyped up syllables?
S. PRABHU1, H. MISRA2, B. AUGIER3 & A. SHERDIL1
1Grenoble Institute of Neurosciences-INSERM U836, UJF-CEA-CHU, Équipe 11, Fonctions Cérébrales et Neuromodulation, Grenoble, France, 2Xerox Research Centre Europe (XRCE), Meylan, France, 3CERAG (UMR 5820), Université Pierre Mendès (UPMF), Grenoble, France
There is a conspicuous trend to extrapolate findings of research in one field to other. This helps in formation of new theories and application of these theories in trans-disciplinary areas. One such prefix is 'neuro'. Brain and its functions were considered outside the domain of humanities and social sciences in the past. The economics, marketing disciplines largely depended on mathematical models and population based surveys to formulate strategies. Except few attempts like controversial 'subliminal messages' in 1957 where principles of psychology were tried in advertisements in an attempt to influence consumer behavior, fusion of neurosciences with these fields was sparse.
Advancement in techniques like functional neuroimaging have provided an impetus to use new phrases like 'neuromarketing' , 'neuroeconomics' and 'neurotheology'. These phrases with suffix 'neuro' have entered not just the scientific domain but are increasingly utilized in news media ,blogs and social networks.
The current study aimed at finding relative abundance of these terms in published literature. We searched the specific web portals like Pubmed and general search engines to enlist documents related to phrases using a prefix 'Neuro'. We then analyzed content of these documents to classify them into scientific articles published in journals and non journal texts in public domains. We also attempted to find a trend in using these phrases by comparing articles published in last year to articles available before 2010. Machine learning tools like latent Dirichlet allocation (LDA) topic model have been used in the past to investigate the rise and fall of topics over a period of time. We have used similar technique to explore the use of the prefix' Neuro' in the recent past in different domains.The findings of current investigation, explanation of possible basis for these results and implications for the society are discussed at the end.
Session Details
Session Title: 20. History, teaching, neuroethics, awareness & social impact
Session Date: Friday, July 15 - Monday, July 18